Aplastic Anaemia



Coding system
CTV3 (Read V3) with TPP extensions
Organisation
OpenSAFELY
Codelist ID
opensafely/aplastic-anaemia
Version
2020-04-24

Versions
  • 2020-04-24

Description

Codes indicating diagnosis of aplastic anaemia

Methodology

This codelist was derived by the following method:

  • Read 2 Codelist provided by LSHTM. See reference for relevant paper.
  • Codes from Quality Outcome Framework (QOF) were examined and relevant aplastic anaemia codes taken
  • Codes from SNOMED were taken by searching for relevant aplastic anaemia terms

These 3 lists were mapped into CTV3 by TPP to create one list. This list was examined by 4 people and the following logic applied (see github issue for more detail):

  • Pure red cell aplasia excluded
  • Pancytopenia NOS was excluded from this list but included in the temporary immunosuppression list
  • T-cell mediated cytopenia excluded as it's thought to be a mechanism to cause aplastic anaemia but also possibly ITP and other single cell line reductions
  • Hypoplastic haemolytic and renal anaemia drugs excluded

References

Signed off by

  • Liam Smeeth, (April 24, 2020)
  • Helen McDonald, (April 23, 2020)

This definition has been computed by taking the manually created full codelist and converting it to a list of rules that define the codelist.

  • (Anaem:[const aplas][fam hypopl])(pancytop+malf)(Black-Diam) (D200.)
  • (RBC aplas/hypoplas: [named variants]) or (Blackf-Diam synd) (D2003)
  • Acquired Fanconi syndrome (X30Jr) and all descendants
  • Acquired aplastic anaemia (XE13t) and all descendants
  • Anaemia: [acquired aplastic] or [normocytic due to aplasia] (D201.)
  • Anaemia: [aplast due drug][hypoplast due drug or chem subst] (D2011)
  • Anaemia: [aplastic and other] or [aplastic] or [hypoblastic] (XE14g)
  • Anaemia: [congen hypoplastic]/[constit aplastic, no malform] (D2000)
  • Aplastic anaemia (D20..)
  • Aplastic anaemia NOS (D20z.)
  • Aplastic anaemia due to chronic disease (D2010)
  • Aplastic anaemia due to drugs (XE13u)
  • Aplastic anaemia due to infection (D2012)
  • Aplastic anaemia due to radiation (D2013)
  • Aplastic anaemia due to toxic cause (D2014)
  • Aplastic and other anaemias (D2...)
  • Congenital Fanconi syndrome (X30Jq)
  • Constitutional aplastic anaemia (XE13q) and all descendants
  • Constitutional aplastic anaemia NOS (D200z)
  • Fanconi's anaemia (D2001)
  • Idiopathic aplastic anaemia (D204.)
  • Other specified constitutional aplastic anaemia (D200y)
  • Pancytopenia with pancreatitis (X20CO)
  • Pancytopenia-dysmelia (XM1Qy)
  • Parvoviral aplastic crisis (X70Jk)
  • Transient hypoplastic anaemia (D2017)
  • [X]Other specified aplastic anaemias (Dyu21)
CTV3ID CTV3PreferredTermDesc CTV3Source
D2... Aplastic and other anaemias CTV3Map_Code_And_Term
D20.. Aplastic anaemia CTV3Map_Code_And_Term
D200. (Anaem:[const aplas][fam hypopl])(pancytop+malf)(Black-Diam) CTV3_Children
D2000 Anaemia: [congen hypoplastic]/[constit aplastic, no malform] CTV3_Children
D2001 Fanconi's anaemia CTV3Map_Code_And_Term
D2001 Fanconi's anaemia CTV3Map_Code_Only
D2003 (RBC aplas/hypoplas: [named variants]) or (Blackf-Diam synd) CTV3_Children
D200y Other specified constitutional aplastic anaemia CTV3Map_Code_And_Term
D200z Constitutional aplastic anaemia NOS CTV3_Children
D201. Anaemia: [acquired aplastic] or [normocytic due to aplasia] CTV3_Children
D2010 Aplastic anaemia due to chronic disease CTV3Map_Code_And_Term
D2011 Anaemia: [aplast due drug][hypoplast due drug or chem subst] CTV3_Children
D2012 Aplastic anaemia due to infection CTV3Map_Code_And_Term
D2012 Aplastic anaemia due to infection CTV3Map_Code_Only
D2013 Aplastic anaemia due to radiation CTV3Map_Code_And_Term
D2013 Aplastic anaemia due to radiation CTV3Map_Code_Only
D2014 Aplastic anaemia due to toxic cause CTV3Map_Code_And_Term
D2014 Aplastic anaemia due to toxic cause CTV3Map_Code_Only
D2017 Transient hypoplastic anaemia CTV3_Children
D204. Idiopathic aplastic anaemia CTV3Map_Code_And_Term
D20z. Aplastic anaemia NOS CTV3Map_Code_And_Term
Dyu21 [X]Other specified aplastic anaemias CTV3_Children
X20CO Pancytopenia with pancreatitis CTV3Map_Code_Only
X20CP Constitutional aplastic anaemia without malformation CTV3Map_Code_And_Term
X20CP Constitutional aplastic anaemia without malformation CTV3Map_Code_Only
X30Jq Congenital Fanconi syndrome CTV3Map_Code_And_Term
X30Jr Acquired Fanconi syndrome CTV3Map_Code_And_Term
X30Jr Acquired Fanconi syndrome CTV3Map_Code_Only
X30Js Adult Fanconi syndrome CTV3Map_Code_And_Term
X70Jk Parvoviral aplastic crisis QOF
XE13q Constitutional aplastic anaemia CTV3Map_Code_And_Term
XE13q Constitutional aplastic anaemia CTV3Map_Code_Only
XE13r Constitutional aplastic anaemia with malformation CTV3Map_Code_And_Term
XE13r Constitutional aplastic anaemia with malformation CTV3Map_Code_Only
XE13t Acquired aplastic anaemia CTV3Map_Code_And_Term
XE13u Aplastic anaemia due to drugs CTV3Map_Code_And_Term
XE13u Aplastic anaemia due to drugs CTV3Map_Code_Only
XE13w Acquired aplastic anaemia NOS CTV3Map_Code_And_Term
XE14g Anaemia: [aplastic and other] or [aplastic] or [hypoblastic] High_Level_SNOMED
XM1Qy Pancytopenia-dysmelia CTV3Map_Code_And_Term
XM1Qy Pancytopenia-dysmelia CTV3Map_Code_Only

Codes not in the full codelist are in faint grey.