OpenSAFELY Codelists: Aplastic Anaemia

Coding system: CTV3 (Read V3) with TPP extensions
Project: OpenSAFELY
Codelist ID: opensafely/aplastic-anaemia
Version: 2020-04-24

Description

Codes indicating diagnosis of aplastic anaemia

Methodology

This codelist was derived by the following method:

Read 2 Codelist provided by LSHTM. See reference for relevant paper.
Codes from Quality Outcome Framework (QOF) were examined and relevant aplastic anaemia codes taken
Codes from SNOMED were taken by searching for relevant aplastic anaemia terms

These 3 lists were mapped into CTV3 by TPP to create one list. This list was examined by 4 people and the following logic applied (see github issue for more detail):

Pure red cell aplasia excluded
Pancytopenia NOS was excluded from this list but included in the temporary immunosuppression list
T-cell mediated cytopenia excluded as it's thought to be a mechanism to cause aplastic anaemia but also possibly ITP and other single cell line reductions
Hypoplastic haemolytic and renal anaemia drugs excluded

References

Signed off by

Liam Smeeth, LSHTM (April 24, 2020)
Helen Macdonald, LSHTM (April 23, 2020)

This definition has been computed by taking the manually created full codelist and converting it to a list of rules that define the codelist.

(Anaemia: [constitutional aplastic] or [familial hypoplastic]) or (pancytopenia with malformations) or (Blackfan - Diamond syndrome) (D200.)
(Red cell: [constitutional aplasia or hypoplasia] or [congenital pure aplasia] or [congenital hypoplasia]) or (Blackfan - Diamond syndrome) (D2003)
Acquired Fanconi syndrome (X30Jr) and all descendants
Acquired aplastic anaemia (XE13t) and all descendants
Anaemia: [acquired aplastic] or [normocytic due to aplasia] (D201.)
Anaemia: [aplastic and other] or [aplastic] or [hypoblastic] (XE14g)
Anaemia: [aplastic due to drugs] or [hypoplastic due to drug or chemical substance] (D2011)
Anaemia: [congenital hypoplastic] or [constitutional aplastic without mention of malformation] (D2000)
Aplastic anaemia (D20..)
Aplastic anaemia NOS (D20z.)
Aplastic anaemia due to chronic disease (D2010)
Aplastic anaemia due to drugs (XE13u)
Aplastic anaemia due to infection (D2012)
Aplastic anaemia due to radiation (D2013)
Aplastic anaemia due to toxic cause (D2014)
Aplastic and other anaemias (D2...)
Congenital Fanconi syndrome (X30Jq)
Constitutional aplastic anaemia (XE13q) and all descendants
Constitutional aplastic anaemia NOS (D200z)
Fanconi's anaemia (D2001)
Idiopathic aplastic anaemia (D204.)
Other specified constitutional aplastic anaemia (D200y)
Pancytopenia with pancreatitis (X20CO)
Pancytopenia-dysmelia (XM1Qy)
Parvoviral aplastic crisis (X70Jk)
Transient hypoplastic anaemia (D2017)
[X]Other specified aplastic anaemias (Dyu21)

CTV3ID	CTV3PreferredTermDesc	CTV3Source
D2...	Aplastic and other anaemias	CTV3Map_Code_And_Term
D20..	Aplastic anaemia	CTV3Map_Code_And_Term
D200.	(Anaem:[const aplas][fam hypopl])(pancytop+malf)(Black-Diam)	CTV3_Children
D2000	Anaemia: [congen hypoplastic]/[constit aplastic, no malform]	CTV3_Children
D2001	Fanconi's anaemia	CTV3Map_Code_And_Term
D2001	Fanconi's anaemia	CTV3Map_Code_Only
D2003	(RBC aplas/hypoplas: [named variants]) or (Blackf-Diam synd)	CTV3_Children
D200y	Other specified constitutional aplastic anaemia	CTV3Map_Code_And_Term
D200z	Constitutional aplastic anaemia NOS	CTV3_Children
D201.	Anaemia: [acquired aplastic] or [normocytic due to aplasia]	CTV3_Children
D2010	Aplastic anaemia due to chronic disease	CTV3Map_Code_And_Term
D2011	Anaemia: [aplast due drug][hypoplast due drug or chem subst]	CTV3_Children
D2012	Aplastic anaemia due to infection	CTV3Map_Code_And_Term
D2012	Aplastic anaemia due to infection	CTV3Map_Code_Only
D2013	Aplastic anaemia due to radiation	CTV3Map_Code_And_Term
D2013	Aplastic anaemia due to radiation	CTV3Map_Code_Only
D2014	Aplastic anaemia due to toxic cause	CTV3Map_Code_And_Term
D2014	Aplastic anaemia due to toxic cause	CTV3Map_Code_Only
D2017	Transient hypoplastic anaemia	CTV3_Children
D204.	Idiopathic aplastic anaemia	CTV3Map_Code_And_Term
D20z.	Aplastic anaemia NOS	CTV3Map_Code_And_Term
Dyu21	[X]Other specified aplastic anaemias	CTV3_Children
X20CO	Pancytopenia with pancreatitis	CTV3Map_Code_Only
X20CP	Constitutional aplastic anaemia without malformation	CTV3Map_Code_And_Term
X20CP	Constitutional aplastic anaemia without malformation	CTV3Map_Code_Only
X30Jq	Congenital Fanconi syndrome	CTV3Map_Code_And_Term
X30Jr	Acquired Fanconi syndrome	CTV3Map_Code_And_Term
X30Jr	Acquired Fanconi syndrome	CTV3Map_Code_Only
X30Js	Adult Fanconi syndrome	CTV3Map_Code_And_Term
X70Jk	Parvoviral aplastic crisis	QOF
XE13q	Constitutional aplastic anaemia	CTV3Map_Code_And_Term
XE13q	Constitutional aplastic anaemia	CTV3Map_Code_Only
XE13r	Constitutional aplastic anaemia with malformation	CTV3Map_Code_And_Term
XE13r	Constitutional aplastic anaemia with malformation	CTV3Map_Code_Only
XE13t	Acquired aplastic anaemia	CTV3Map_Code_And_Term
XE13u	Aplastic anaemia due to drugs	CTV3Map_Code_And_Term
XE13u	Aplastic anaemia due to drugs	CTV3Map_Code_Only
XE13w	Acquired aplastic anaemia NOS	CTV3Map_Code_And_Term
XE14g	Anaemia: [aplastic and other] or [aplastic] or [hypoblastic]	High_Level_SNOMED
XM1Qy	Pancytopenia-dysmelia	CTV3Map_Code_And_Term
XM1Qy	Pancytopenia-dysmelia	CTV3Map_Code_Only

Codes in the definition are underlined. Codes in the full codelist are in blue. Related codes not in the codelist are in black.