OpenSAFELY Codelists: Chronic Liver Disease

Coding system: CTV3 (Read V3) with TPP extensions
Project: OpenSAFELY
Codelist ID: opensafely/chronic-liver-disease
Version: 2020-06-02

Description

Code indicating diagnosis of chronic liver disease

Methodology

This codelist was derived by the following method:

Read 2 Codelist provided by LSHTM
Codes from Quality Outcome Framework (QOF) were examined and relevant liver codes taken
Codes from SNOMED were taken by searching for relevant liver terms

These 3 lists were mapped into CTV3 by TPP to create one list. This list was examined by 2 people and the following logic applied (see github issue for more detail):

Multi-system genetic disease (such a glycogen storage diseases) excluded as although liver disease can be part of this presentation, it may not progress to include liver disease
Inclusion of all chronic viral hepatitis disease
Inclusion of signs of cirrhosis such as oesophageal varices
Inclusion of liver transplant (recipient only)

References

Discussion on GitHub issue

Signed off by

Caroline Morton, EBM Datalab (April 7, 2020)
Alex Walker, EBM Datalab (April 7, 2020)

This definition has been computed by taking the manually created full codelist and converting it to a list of rules that define the codelist.

(Cirrhos &/or chron liver dis) or (alcoholic liver disease) (XE0dD)
Alcoholic liver disease (X3071) and all descendants
Atresia of bile ducts (PB61.) and all descendants
Atresia of hepatic ducts (PB616)
Autoimmune hepatitis (XaJTk)
Balloon tamponade of oesophagus (760J4) and all descendants
Chronic hepatitis (J614.) and all descendants except:
- Hepatitis B carrier (X306n)
- Hepatitis C carrier (X306o)
Chronic hepatitis annual review (XaPLW)
Chronic liver disease NOS (J61z.)
Chronic passive congestion of liver (J630.)
Chronic yellow atrophy (J61y0)
Cirrhosis of liver (X307L) and all descendants except:
- Cardituberculous cirrhosis (J615E)
Congenital absence of bile duct (PB610)
Congenital absence of hepatic ducts (PB615)
Exploration liver (& transplanted) (78052)
Exploration of liver transplant (X20Zz)
Fibreopt endoscop rubber band ligation of upper GIT varices (XaLdJ)
Fibreoptic oesophagoscopy & injection sclerotherapy varices (760C3)
Fibreoptic oesophagoscopy and banding of oesophageal varices (760C5)
Gastric varices (G857.)
Hepatic failure (X3076) and all descendants
Hepatic granulomas in sarcoidosis (J63A.)
Ichthyosis congenita with biliary atresia (X3085)
Liver abscess and sequelae of chronic liver disease (J62..) and all descendants
Liver disease due to cystic fibrosis (XaREa)
Liver transplant (7800.) and all descendants
Liver transplant disorder (X307x) and all descendants
Local ligation of oesophageal varices (76093)
Oesophageal varices (X2063) and all descendants
Open injection sclerotherapy to oesophageal varices (76094)
Open operations on oesophageal varices (7609.) and all descendants
Other non-alcoholic chronic liver disease (J61y.) and all descendants
Other sequelae of chronic liver disease (XE0bC)
Other specified viral hepatitis with coma (A704.) and all descendants
Portal fibrosis without cirrhosis (J61y3)
Portal hypertension (J623.)
Progressive neuronal degeneration with liver cirrhosis (F10y0)
Recurrent hepatitis (J6143)
Rigid oesophagoscopy and banding of oesophageal varices (760F4)
Rigid oesophagoscopy and injection sclerotherapy of varices (760F3)
Toxic liver disease with chronic active hepatitis (J6355)
Toxic liver disease with chronic lobular hepatitis (J6354)
Toxic liver disease with chronic persistent hepatitis (J6353)
Toxic liver disease with fibrosis and cirrhosis of liver (J6356)
Unspecified viral hepatitis with coma (A706.)
Viral hepatitis C with coma (A7040)
Viral hepatitis with hepatic coma (XaYbp)
[V]Assessment for liver transplant (ZV7C0)
[V]Liver transplanted (ZV427)
[X]Chronic viral hepatitis, unspecified (AyuB2)
[X]Other and unspecified cirrhosis of liver (Jyu71)
[X]Other chronic viral hepatitis (AyuB1)
[X]Unspecified viral hepatitis with coma (AyuB3)

CTV3ID	CTV3PreferredTermDesc	CTV3Source
7609.	Open operations on oesophageal varices	CTV3Map_Code_And_Term
76093	Local ligation of oesophageal varices	CTV3Map_Code_And_Term
76094	Open injection sclerotherapy to oesophageal varices	CTV3Map_Code_And_Term
7609y	Oesophageal varices operation: [OS open] or [Tanner]	CTV3_Children
7609z	Open operation on oesophageal varices NOS	CTV3Map_Code_And_Term
760C3	Fibreoptic oesophagoscopy & injection sclerotherapy varices	CTV3Map_Code_And_Term
760C5	Fibreoptic oesophagoscopy and banding of oesophageal varices	CTV3Map_Code_And_Term
760F3	Rigid oesophagoscopy and injection sclerotherapy of varices	CTV3Map_Code_And_Term
760F4	Rigid oesophagoscopy and banding of oesophageal varices	CTV3Map_Code_And_Term
760J4	Balloon tamponade of oesophagus	CTV3Map_Code_And_Term
7800.	Liver transplant	CTV3Map_Code_And_Term
78000	Orthotopic liver transplant	CTV3Map_Code_And_Term
78001	Heterotopic liver transplant	CTV3Map_Code_And_Term
78001	Heterotopic liver transplant	CTV3Map_Code_Only
78002	Replacement of previous liver transplant	CTV3Map_Code_And_Term
7800y	Other specified transplantation of liver	CTV3Map_Code_And_Term
7800z	Transplantation of liver NOS	CTV3Map_Code_And_Term
78052	Exploration liver (& transplanted)	CTV3_Children
A704.	Other specified viral hepatitis with coma	CTV3Map_Code_And_Term
A7040	Viral hepatitis C with coma	CTV3Map_Code_And_Term
A704z	Other specified viral hepatitis with hepatic coma NOS	CTV3Map_Code_And_Term
A706.	Unspecified viral hepatitis with coma	CTV3Map_Code_And_Term
A7071	Chronic viral hepatitis B without delta-agent	CTV3Map_Code_And_Term
A7072	Chronic viral hepatitis C	CTV3_Children
AyuB1	[X]Other chronic viral hepatitis	CTV3Map_Code_And_Term
AyuB2	[X]Chronic viral hepatitis, unspecified	CTV3Map_Code_And_Term
AyuB3	[X]Unspecified viral hepatitis with coma	CTV3Map_Code_And_Term
F10y0	Progressive neuronal degeneration with liver cirrhosis	CTV3Map_Code_And_Term
G850.	Bleeding oesophageal varices	CTV3Map_Code_And_Term
G851.	Oesophageal varices without bleeding	CTV3Map_Code_And_Term
G852.	Oesophageal varices in diseases EC	CTV3Map_Code_And_Term
G8520	Oesophageal varices with bleeding in diseases EC	CTV3Map_Code_And_Term
G8521	Oesophageal varices without bleeding in diseases EC	CTV3Map_Code_And_Term
G852z	Oesophageal varices in diseases EC NOS	CTV3Map_Code_And_Term
G857.	Gastric varices	CTV3Map_Code_And_Term
Gyu94	[X]Oesophageal varices in diseases classified elsewhere	CTV3Map_Code_And_Term
J6000	Acute hepatic failure	CTV3_Children
J6010	Subacute hepatic failure	CTV3_Children
J61..	Cirrhosis and chronic liver disease	CTV3Map_Code_And_Term
J610.	Alcoholic fatty liver	High_Level_SNOMED
J611.	Acute alcoholic hepatitis	High_Level_SNOMED
J612.	Cirrhosis: [florid] or [alcoholic]	High_Level_SNOMED
J613.	Alcoholic liver damage unspecified	High_Level_SNOMED
J614.	Chronic hepatitis	CTV3Map_Code_And_Term
J6140	Chronic persistent hepatitis	CTV3Map_Code_And_Term
J6141	Chronic active hepatitis	CTV3Map_Code_And_Term
J6142	Chronic aggressive hepatitis	CTV3Map_Code_And_Term
J6143	Recurrent hepatitis	QOF
J614y	Chronic hepatitis unspecified	CTV3Map_Code_And_Term
J614z	Chronic hepatitis NOS	CTV3Map_Code_And_Term
J615.	(Cirrhosis - non alcoholic) or (portal cirrhosis)	High_Level_SNOMED
J6150	Unilobular portal cirrhosis	QOF
J6151	Cirrhosis of liver: [multilobular portal] or [postnecrotic]	QOF
J6152	Mixed portal cirrhosis	QOF
J6153	Diffuse nodular cirrhosis	CTV3Map_Code_And_Term
J6154	Fatty portal cirrhosis	CTV3Map_Code_And_Term
J6155	Macronodular cirrhosis	CTV3Map_Code_And_Term
J6156	Capsular portal cirrhosis	CTV3Map_Code_And_Term
J6157	Cirrhosis: [cardiac portal] or [congestive]	CTV3_Children
J6158	Cirrhosis: [juv portal] or [childh funct] or [Indian childh]	High_Level_SNOMED
J6159	Pigmentary portal cirrhosis	QOF
J615A	Pipestem portal cirrhosis	CTV3_Children
J615B	Toxic portal cirrhosis	QOF
J615D	Bacterial portal cirrhosis	CTV3Map_Code_And_Term
J615F	Syphilitic portal cirrhosis	CTV3Map_Code_And_Term
J615G	Zooparasitic portal cirrhosis	CTV3Map_Code_And_Term
J615H	Infectious cirrhosis NOS	CTV3Map_Code_And_Term
J615y	Portal cirrhosis unspecified	CTV3Map_Code_And_Term
J615z	(Liver cirrhos: [named vars] or [NOS]) or (hepat fibrosis)	High_Level_SNOMED
J616.	Biliary cirrhosis	CTV3Map_Code_And_Term
J6160	Primary biliary cirrhosis	CTV3Map_Code_And_Term
J6161	Secondary biliary cirrhosis	CTV3Map_Code_And_Term
J6162	Biliary cirrhosis of children	CTV3Map_Code_And_Term
J616z	Biliary cirrhosis NOS	CTV3Map_Code_And_Term
J617.	Alcoholic hepatitis	High_Level_SNOMED
J61y.	Other non-alcoholic chronic liver disease	CTV3Map_Code_And_Term
J61y0	Chronic yellow atrophy	QOF
J61y3	Portal fibrosis without cirrhosis	CTV3Map_Code_And_Term
J61yz	Other non-alcoholic chronic liver disease NOS	CTV3Map_Code_And_Term
J61z.	Chronic liver disease NOS	CTV3Map_Code_And_Term
J62..	Liver abscess and sequelae of chronic liver disease	CTV3Map_Code_And_Term
J623.	Portal hypertension	CTV3Map_Code_And_Term
J624.	Hepatorenal syndrome	CTV3Map_Code_And_Term
J62z.	Liver abscess and chronic liver disease causing sequelae NOS	CTV3Map_Code_And_Term
J630.	Chronic passive congestion of liver	QOF
J6353	Toxic liver disease with chronic persistent hepatitis	CTV3Map_Code_And_Term
J6354	Toxic liver disease with chronic lobular hepatitis	CTV3Map_Code_And_Term
J6355	Toxic liver disease with chronic active hepatitis	CTV3Map_Code_And_Term
J6356	Toxic liver disease with fibrosis and cirrhosis of liver	CTV3Map_Code_And_Term
J63A.	Hepatic granulomas in sarcoidosis	CTV3Map_Code_And_Term
J6617	Primary sclerosing cholangitis	CTV3Map_Code_And_Term
Jyu71	[X]Other and unspecified cirrhosis of liver	CTV3Map_Code_And_Term
PB61.	Atresia of bile ducts	CTV3Map_Code_And_Term
PB610	Congenital absence of bile duct	CTV3Map_Code_And_Term
PB611	Congenital hypoplasia of bile duct	CTV3Map_Code_And_Term
PB614	Atresia of bile duct (& [intrahepatic] or [extrahepatic]	CTV3_Children
PB615	Congenital absence of hepatic ducts	CTV3Map_Code_And_Term
PB616	Atresia of hepatic ducts	CTV3Map_Code_And_Term
PB61z	Biliary atresia NOS	CTV3Map_Code_And_Term
PB635	Alagille syndrome	CTV3Map_Code_And_Term
SP086	Liver transplant failure and rejection	CTV3Map_Code_And_Term
SP142	Hepatic failure as a complication of care	CTV3_Children
SP143	Hepatorenal syndrome as a complication of care	CTV3Map_Code_And_Term
X2063	Oesophageal varices	CTV3Map_Code_And_Term
X20Uu	Balln tamponade oesophagus using Sengstaken-Blakemore tube	CTV3Map_Code_And_Term
X20Uv	Balloon tamponade of oesophagus using Minnesota tube	CTV3_Children
X20Zz	Exploration of liver transplant	CTV3Map_Code_And_Term
X306h	Chronic viral hepatitis	CTV3Map_Code_And_Term
X306i	Chronic viral hepatitis B	CTV3Map_Code_And_Term
X306j	Chronic viral hepatitis B with hepatitis D	CTV3Map_Code_And_Term
X306k	Chronic viral hepatitis C	CTV3Map_Code_And_Term
X306l	Chronic non-A non-B hepatitis	CTV3_Children
X306r	Alcoholic hepatitis	High_Level_SNOMED
X3071	Alcoholic liver disease	High_Level_SNOMED
X3072	Alcoholic fibrosis and sclerosis of liver	CTV3Map_Code_And_Term
X3073	Alcoholic hepatic failure	CTV3Map_Code_And_Term
X3076	Hepatic failure	CTV3Map_Code_Only
X3077	Liver failure NOS	CTV3Map_Code_Only
X3078	Hepatic failure NOS	CTV3Map_Code_Only
X3079	Fulminant hepatic failure	CTV3_Children
X307A	Subfulminant hepatic failure	CTV3_Children
X307C	Chronic hepatic failure	CTV3_Children
X307G	Chronic lobular hepatitis	CTV3Map_Code_And_Term
X307I	Drug-induced chronic hepatitis	CTV3_Children
X307L	Cirrhosis of liver	QOF
X307M	Cirrhosis of liver NOS	CTV3Map_Code_And_Term
X307N	Florid cirrhosis	CTV3Map_Code_And_Term
X307O	Cryptogenic cirrhosis	CTV3Map_Code_And_Term
X307P	Indian childhood cirrhosis	CTV3Map_Code_And_Term
X307Q	Micronodular cirrhosis	QOF
X307R	Portal cirrhosis	CTV3Map_Code_And_Term
X307S	Laennec's cirrhosis, non-alcoholic	CTV3Map_Code_Only
X307T	Infectious cirrhosis	QOF
X307U	Hypoxia-associated cirrhosis	QOF
X307V	Toxic cirrhosis	QOF
X307W	Fibrosis of liver	CTV3Map_Code_And_Term
X307X	Congenital hepatic fibrosis	CTV3_Children
X307Y	Pericellular fibrosis of congenital syphilis	CTV3_Children
X307Z	Hepatic sclerosis	CTV3Map_Code_And_Term
X307a	Portal and splenic vein sclerosis	CTV3_Children
X307b	Hepatic fibrosis with hepatic sclerosis	CTV3Map_Code_And_Term
X307c	Intrahepatic phlebosclerosis and fibrosis	CTV3_Children
X307x	Liver transplant disorder	High_Level_SNOMED
X307y	Liver transplant rejection	High_Level_SNOMED
X307z	Liver transplant failure	High_Level_SNOMED
X3085	Ichthyosis congenita with biliary atresia	QOF
X7847	Intrahepatic biliary atresia	CTV3Map_Code_And_Term
X7848	Extrahepatic biliary atresia	CTV3Map_Code_And_Term
XE0CP	Other specified open operation on oesophageal varices	CTV3Map_Code_And_Term
XE0b4	Alcoholic cirrhosis of liver	CTV3Map_Code_And_Term
XE0b5	Cirrhosis - non-alcoholic	CTV3Map_Code_And_Term
XE0b6	Multilobular portal cirrhosis	CTV3Map_Code_And_Term
XE0b7	Cardiac portal cirrhosis	CTV3Map_Code_And_Term
XE0b8	Juvenile portal cirrhosis	CTV3Map_Code_And_Term
XE0bA	Non-alcoholic cirrhosis NOS	CTV3Map_Code_And_Term
XE0bC	Other sequelae of chronic liver disease	CTV3Map_Code_And_Term
XE0dD	(Cirrhos &/or chron liver dis) or (alcoholic liver disease)	High_Level_SNOMED
XE0dF	Alcoholic liver damage NOS	High_Level_SNOMED
XE0dH	Chronic hepatitis (& [NOS]/[active B]/[active]/[persistent])	CTV3_Children
XE0dJ	Biliary cirrhosis (& [primary])	CTV3_Children
XE2up	Cirrhosis secondary to cholestasis	CTV3Map_Code_And_Term
Xa9C7	Cardiac cirrhosis	CTV3Map_Code_And_Term
XaBE3	Chronic alcoholic hepatitis	CTV3Map_Code_And_Term
XaBM6	Oesophageal varices in cirrhosis of the liver	CTV3Map_Code_And_Term
XaC1d	Oesophageal varices in alcoholic cirrhosis of the liver	CTV3Map_Code_And_Term
XaE6u	Oesophageal varices NOS	CTV3Map_Code_And_Term
XaJTk	Autoimmune hepatitis	CTV3Map_Code_And_Term
XaJxp	Acute hepatic failure due to drugs	CTV3_Children
XaLdJ	Fibreopt endoscop rubber band ligation of upper GIT varices	CTV3Map_Code_And_Term
XaLde	Transplantation of liver cells	CTV3_Children
XaLdf	Orthotopic transplantation of whole liver	CTV3Map_Code_And_Term
XaMMe	Orthotopic transplantation of liver NEC	CTV3Map_Code_And_Term
XaMuG	Compensation for liver failure	CTV3Map_Code_And_Term
XaMuH	Other specified compensation for liver failure	CTV3_Children
XaMuI	Compensation for liver failure NOS	CTV3Map_Code_And_Term
XaPLW	Chronic hepatitis annual review	CTV3Map_Code_And_Term
XaREa	Liver disease due to cystic fibrosis	CTV3Map_Code_And_Term
XaXi9	Cystic fibrosis related cirrhosis	CTV3Map_Code_And_Term
XaYbp	Viral hepatitis with hepatic coma	CTV3Map_Code_And_Term
ZV427	[V]Liver transplanted	QOF
ZV7C0	[V]Assessment for liver transplant	CTV3Map_Code_And_Term

Codes not in the full codelist are in faint grey.