Venous Thromboembolic Disease



Coding system
CTV3 (Read V3)
Project
OpenSAFELY
Codelist ID
opensafely/venous-thromboembolic-disease
Version
2020-09-14

Description

DEFINITION: A history of venous thromboembolic disease

Variables: (1) a binary variable denoting the presence of one of the codes at any point in the patient record. (2) the earliest date of such a code.

Methodology

Process (1) Read 2 code list from Helen Strongman and Angel Wong combined here: We did not include codes for suspected/possible DVT/PE; nor PEs specified as air embolism or amniotic fluid embolism as would not indicate at ongoing risk of a venous thrombosis/clot. (2) SNOMED searched for DVT and PE

didn't include air embolisms, fat embolisms, or amniotic fluid embolisms or suspected PE assumed unspecified PEs were blood clots. (3) mapped to CTV3 and reviewed by Helen McDonald and Amir Mehrkar, principles discussed with Laurie Tomlinson as above. To reflect the conversation, HM updated the spreadsheet with a final recommendation CTV3<em>venous</em>thromboembolism<em>combining</em>comments.xlsx FLEXIBILITY NEEDED BETWEEN STUDIES: This list

doesn't include fat pulmonary embolism, air pulmonary embolism or amniotic fluid pulmonary embolism (though assumes unspecified PEs are thromboembolic) includes codes for any history of DVT or PE - studies of incident DVT/PE may wish to exclude these. includes codes for PE/DVT in pregnancy, which may not be relevant for all studies includes codes for cerebral venous thrombosis (which may be caused by cerebral inflammation eg. meningitis and is only very rarely associated with PE) and portal thrombosis (which may be caused by liver pathology and should not be able to result in PE) and mesenteric thrombosis, not all of which may be relevant for other study questions. EFFECTS ON COHORT SELECTION: None

POTENTIAL BIASES: This variable includes a history of any venous thrombosis. Some DVTs/PEs will have occurred in the context of a temporary condition (e.g. pregnancy, meningitis, immobility), and some individuals identified by this codelist will be at higher risk of future DVT/PE than others

References

Signed off by

  • Helen Macdonald, LSHTM (Sept. 8, 2020)
  • Amir Mehrkar, EBM Datalab (Sept. 10, 2020)

This definition has been computed by taking the manually created full codelist and converting it to a list of rules that define the codelist.

CTV3Code CTV3PreferredTermDesc CTV3Source Include
14A8. H/O: [thrombo-embolism] or [embolism] or [thrombosis] High_Level_SNOMED 1
14A81 H/O: Deep Vein Thrombosis CTV3Map_Code_And_Term 1
14AC. H/O: pulmonary embolus CTV3Map_Code_And_Term 1
7A093 Open pulmonary embolectomy CTV3Map_Code_And_Term 1
7A093 Open pulmonary embolectomy CTV3Map_Code_Only 1
F05.. Phlebitis and thrombophlebitis of intracranial sinuses CTV3Map_Code_And_Term 1
F051. Cerebral venous sinus thrombosis CTV3Map_Code_And_Term 1
F0510 Cerebral venous thrombosis of cavernous sinus CTV3_Children 1
F0511 Thrombosis of superior longitudinal sinus CTV3_Children 1
F0512 Cerebral venous thrombosis of lateral sinus CTV3_Children 1
F0513 Thrombosis transverse sinus CTV3_Children 1
F051z Thrombosis of central nervous system venous sinus NOS CTV3Map_Code_And_Term 1
F053. Thrombophlebitis of central nervous system venous sinuses CTV3Map_Code_And_Term 1
F0530 Thrombophlebitis of cavernous sinus CTV3Map_Code_And_Term 1
F0531 Thrombophlebitis of superior longitudinal venous sinus CTV3Map_Code_And_Term 1
F05z. Phlebitis or thrombophlebitis of CNS venous sinus NOS CTV3Map_Code_And_Term 1
G4010 Postoperative pulmonary embolus CTV3Map_Code_And_Term 1
G676. Non-pyogenic venous sinus thrombosis CTV3Map_Code_And_Term 1
G801. (Deep vein phlebitis/thrombophleb leg) or (deep vein thromb) High_Level_SNOMED 1
G8016 Thrombophlebitis of the femoral vein CTV3Map_Code_And_Term 1
G8017 Thrombophlebitis of the popliteal vein CTV3Map_Code_And_Term 1
G8018 Thrombophlebitis of the anterior tibial vein CTV3Map_Code_And_Term 1
G8019 Thrombophlebitis of the dorsalis pedis vein CTV3Map_Code_And_Term 1
G801A Thrombophlebitis of the posterior tibial vein CTV3Map_Code_And_Term 1
G801B Deep vein thrombophlebitis of the leg unspecified CTV3Map_Code_And_Term 1
G801z Deep vein phlebitis and thrombophlebitis of the leg NOS CTV3Map_Code_And_Term 1
G80y. (Phleb/thrombophleb iliac vein) or (oth phleb/thrombophleb) High_Level_SNOMED 1
G80y4 Thrombophlebitis of the common iliac vein CTV3Map_Code_And_Term 1
G80y5 Thrombophlebitis of the internal iliac vein CTV3Map_Code_And_Term 1
G80y6 Thrombophlebitis of the external iliac vein CTV3Map_Code_And_Term 1
G80y7 Thrombophlebitis of the iliac vein unspecified CTV3Map_Code_And_Term 1
G80y8 Phlebitis and thrombophlebitis of the iliac vein NOS CTV3Map_Code_And_Term 1
G81.. Portal vein thrombosis CTV3Map_Code_And_Term 1
G822. Embolism and thrombosis of the vena cava CTV3Map_Code_And_Term 1
J4202 Superior mesenteric vein thrombosis CTV3Map_Code_And_Term 1
L0964 Pulmonary embolism following abortive pregnancy CTV3Map_Code_And_Term 1
L413. Antenatal deep vein thrombosis CTV3_Children 1
L4130 Antenatal deep vein thrombosis unspecified CTV3_Children 1
L4131 Antenatal deep vein thrombosis - delivered CTV3_Children 1
L4132 Antenatal deep vein thrombosis with antenatal complication CTV3_Children 1
L413z Antenatal deep vein thrombosis NOS CTV3_Children 1
L414. DVT: [postnatal] or [obstetric phlegmasia alba dolens] CTV3_Children 1
L4140 Postnatal deep vein thrombosis unspecified CTV3_Children 1
L4141 Postnatal deep vein thrombosis - delivered with p/n comp CTV3_Children 1
L4142 Postnatal deep vein thrombosis with postnatal complication CTV3_Children 1
L414z Postnatal deep vein thrombosis NOS CTV3_Children 1
L417. Obstetric cerebral venous thrombosis CTV3_Children 1
L4170 Cerebral venous thrombosis in pregnancy CTV3_Children 1
L4171 Cerebral venous thrombosis in the puerperium CTV3_Children 1
L43.. Obstetric pulmonary embolism CTV3Map_Code_And_Term 1
L43.. Obstetric pulmonary embolism CTV3Map_Code_Only 1
L432. Obstetric blood-clot pulmonary embolism CTV3Map_Code_And_Term 1
L4320 Obstetric blood-clot pulmonary embolism unspecified CTV3_Children 1
L4321 Obstetric blood-clot pulmonary embolism - delivered CTV3_Children 1
L4322 Obstetric blood-clot pulm embolism - delivered with p/n comp CTV3_Children 1
L4323 Obstetric blood-clot pulmonary embolism + a/n complication CTV3_Children 1
L4324 Obstetric blood-clot pulmonary embolism + p/n complication CTV3_Children 1
L432z Obstetric blood-clot pulmonary embolism NOS CTV3_Children 1
L43y0 Other obstetric pulmonary embolism unspecified CTV3_Children 1
L43y1 Other obstetric pulmonary embolism - delivered CTV3_Children 1
L43y2 Other obstetric pulmonary embolism - delivered + p/n comp CTV3_Children 1
L43y3 Other obstetric pulmonary embolism with antenatal comp CTV3_Children 1
L43y4 Other obstetric pulmonary embolism with postnatal comp CTV3_Children 1
L43yz Other obstetric pulmonary embolism NOS CTV3Map_Code_And_Term 1
L43z. Obstetric pulmonary embolism NOS CTV3Map_Code_And_Term 1
L43z0 Obstetric pulmonary embolism NOS, unspecified CTV3Map_Code_And_Term 1
L43z1 Obstetric pulmonary embolism NOS - delivered CTV3Map_Code_And_Term 1
L43z2 Obstetric pulmonary embolism NOS - delivered with p/n comp CTV3_Children 1
L43z3 Obstetric pulmonary embolism NOS with antenatal complication CTV3_Children 1
L43z4 Obstetric pulmonary embolism NOS with postnatal complication CTV3_Children 1
Lyu64 [X]Other obstetric embolism CTV3_Children 1
SP122 Postoperative deep vein thrombosis CTV3Map_Code_And_Term 1
X00Dj Cerebral venous thrombosis of sagittal sinus CTV3_Children 1
X00Dk Cerebral venous thrombosis of straight sinus CTV3_Children 1
X00Dl Cerebral venous thrombosis of sigmoid sinus CTV3_Children 1
X00Dm Cerebral venous thrombosis of cortical vein CTV3_Children 1
X012b Operation for pulmonary embolism High_Level_SNOMED 1
X012d Transluminal fragmentation of pulmonary embolus High_Level_SNOMED 1
X202x Pulmonary thromboembolism CTV3_Children 1
X202y Acute massive pulmonary embolism CTV3_Children 1
X202z Subacute massive pulmonary embolism CTV3_Children 1
X205e Deep thrombophlebitis High_Level_SNOMED 1
X205m Lower venous segment thrombosis CTV3_Children 1
X205n Ileofemoral deep vein thrombosis CTV3_Children 1
X76Lg Phlegmasia alba dolens CTV3_Children 1
X76Lh Phlegmasia caerula dolens CTV3_Children 1
XE0Um Pulmonary embolus CTV3Map_Code_And_Term 1
XE0Um Pulmonary embolus CTV3Map_Code_Only 1
XE0VY Deep vein phlebitis and thrombophlebitis of the leg CTV3Map_Code_And_Term 1
XE0VY Deep vein phlebitis and thrombophlebitis of the leg CTV3Map_Code_Only 1
XE0Va Budd-Chiari syndrome CTV3Map_Code_And_Term 1
XE0Va Budd-Chiari syndrome CTV3Map_Code_Only 1
XE0XS (Deep ven thromb leg)(nonpuer milk-leg)(deep thrombophl leg) CTV3_Children 1
XE0q9 H/O: thromboembolism High_Level_SNOMED 1
XE0xL Postnatal deep vein thrombosis CTV3_Children 1
XE0xN Other obstetric pulmonary embolism CTV3_Children 1
Xa07G Phlebitis and/or thrombophlebitis of iliac vein CTV3Map_Code_And_Term 1
Xa1aj Phlegmasia alba dolens - obstetric CTV3_Children 1
Xa1oU Thrombosis of inferior vena cava CTV3Map_Code_And_Term 1
Xa1oV Thrombosis of superior vena cava High_Level_SNOMED 1
Xa6Yr Axillary vein thrombosis High_Level_SNOMED 1
Xa9Bs Deep vein thrombosis of lower limb CTV3Map_Code_And_Term 1
Xa9Bs Deep vein thrombosis of lower limb CTV3Map_Code_Only 1
XaBMc [V] Personal history deep vein thrombosis CTV3Map_Code_And_Term 1
XaBMc [V] Personal history deep vein thrombosis CTV3Map_Code_Only 1
XaBMd [V] Personal history of pulmonary embolism CTV3Map_Code_And_Term 1
XaDyD Thrombophlebitis of iliac vein High_Level_SNOMED 1
XaIIo Deep vein thrombosis of leg related to air travel CTV3Map_Code_And_Term 1
XaJxo Deep vein thrombosis of leg related to intravenous drug use CTV3Map_Code_And_Term 1
XaOYV Recurrent pulmonary embolism CTV3Map_Code_And_Term 1
XaQIV Deep venous thrombosis of peroneal vein CTV3Map_Code_And_Term 1
XaZ43 Recurrent deep vein thrombosis CTV3Map_Code_And_Term 1
XaZHi H/O venous thromboembolism High_Level_SNOMED 1
XaZht Thrombosis of subclavian vein High_Level_SNOMED 1
Xaa2K Thrombosis of internal jugular vein High_Level_SNOMED 1
Xacvd Unprovoked deep vein thrombosis CTV3Map_Code_And_Term 1
Xacve Provoked deep vein thrombosis CTV3Map_Code_And_Term 1

Codes in the definition are underlined. Codes in the full codelist are in blue. Related codes not in the codelist are in black.